Human TNF α 

Cat# BB-PE0170 100µg (1mg/ml)

Product type: Human tumor necrosis factor alpha (TNFα) extracellular domain

Source: Recombinant protein expressed in E. coli

Other Name: TNFSF1A, TNFSF2

Protein Sequence:

MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQREESP
RDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELRDNQL
VVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRETPEGAEAKP
WYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL

Purity: Greater than 98% evaluated based on SDS-PAGE

Formulation: Supplied as a 0.2 μm filtered solution in PBS at 100 μg (1mg/ml) containing 50% Glycerol.  

Specificity: Acts both on human and murine cell lines

Description: Tumor necrosis factor alpha (TNF-α) is a member of the TNF superfamily. It is a pleiotropic molecule that plays a central role in inflammation and immune system development. TNF-α is produced by a wide variety of cell types including lymphoid cells. TNFa matures through separation of the extracellular domain from rest of the molecule.  It forms a soluble trimer which binds the trimeric TNF receptor (TNFR). TNF-α is a key cytokine in the development of several inflammatory disorders.

Storage: Store at -20°C (Recommended).